Can San Francisco cover one of the tightest NFL spreads of the 2022 NFL playoffs? All of the championship round NFL lines are listed below and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best NFL picks now. In two games played this season, the Niners emerged victorious over L.A., 31-10 and 27-24. The 49ers beat the Rams twice already this year and Los Angeles hasn't defeated San Francisco since the final week of the 2018-19 season.
In its latest NFL odds, Caesars Sportsbook lists the Rams as likely to make it back this year as 3.5-point favorites over the 49ers in Sunday's 2022 NFC Championship Game. Just two games remain before the 2022 Super Bowl, and three teams playing in Sunday's conference championship games have an appearance in the big game within the last three years.
